Lem3, a phospholipid flippase subunit, influences <i>Candida albicans</i> pathogenicity through maintenance of plasma membrane asymmetry
pathogenicity. Together, these findings position Lem3 and the flippase machinery as promising targets for antifungal therapy. IMPORTANCE: . These findings highlight how diverse cellular processes are interconnected through flippase-mediated lipid homeostasis. With the alarming rise in fungal infections and antifungal resistance, targeting lipid translocators such as Lem3 offers a promising avenue for the development of novel therapeutic targets.
Authors
- Clarissa J. Nobile (ORCID: https://orcid.org/0000-0003-0799-6499)
- Joachim Morschhäuser (ORCID: https://orcid.org/0000-0003-4227-8687)
- Sneh Lata Panwar (ORCID: https://orcid.org/0000-0003-0848-8306)
- David R. Andes (ORCID: https://orcid.org/0000-0002-7927-9950)
- Priya Uppuluri (ORCID: https://orcid.org/0000-0002-5889-054X)
- Mélanie A. C. Ikeh (ORCID: https://orcid.org/0000-0002-6767-1058)
- Pranjali Agrawal
- Sunna Nabeela (ORCID: https://orcid.org/0000-0002-8066-2199)
- Basharat Ali
- Pritam Kumar
Institutions
- University of Wisconsin–Madison (US)
- Jawaharlal Nehru University (IN)
- University of Würzburg (DE)
- Los Angeles Medical Center (US)
- Amity University (AE)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1128/spectrum.02965-25
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Department of Science and Technology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- National Institute of General Medical Sciences