Association between pre-operative computed tomography-based adipose tissue quantification and post-transplant dyslipidemia in renal transplantation recipients

Background: There is an established correlation between obesity and dyslipidemia in individuals who have undergone kidney transplantation (KT). Body composition is a more accurate indicator of obesity than body mass index (BMI). However, the relationship between pre-operative body composition and post-transplant dyslipidemia remains unexplored. Methods: We analyzed 333 participants who underwent KT between 2021 and 2024. Using pre-transplantation computed tomography (CT), we assessed the cross-sectional areas of skeletal muscle (SM) and adipose tissue at the level of the third lumbar vertebra. Participants were categorized into high and low body composition groups based on the highest quartile, and into dyslipidemia and non-dyslipidemia groups according to post-transplant blood lipid levels. Skeletal muscle (SM) and adipose tissue metrics were subsequently used to model dyslipidemia after KT. Generalized estimating equations (GEE) were then employed to assess the impact of body composition on blood lipid levels at 45 days, and at 3, 6 months, and 1 year post-transplant. Results: = 0.033). Conclusions: High pre-transplant VAT was associated with low HDL-C, elevated TG, and LDL-C levels after KT. These findings may have significant implications for reducing the incidence of dyslipidemia post-KT.