Structure-Based Design of a Novel Covalent 4-(1-Methylindol-3-yl)pyrimidin-2-amine Series Targeting FGFR2 Resistance Mutations

Authors

Samhita Iyer (ORCID: https://orcid.org/0000-0002-9514-5477)
Jacqueline H. Starrett (ORCID: https://orcid.org/0000-0002-4970-7491)
Isaac Hoffman (ORCID: https://orcid.org/0000-0003-2694-802X)
Kirk Nelson (ORCID: https://orcid.org/0000-0003-1160-5251)
Alexandra Balcer
Melissa Neal
Ronald V. Swanson (ORCID: https://orcid.org/0000-0002-6486-2676)
Robert L. Hudkins
Daniel C. Bensen
Qing Ye (ORCID: https://orcid.org/0000-0003-4340-9925)
Todd J. Harris
Marc Rideout
Eric Allen
Caleb B. Frye

Institutions

State Street (United States) (US)
Nanospectra Biosciences (United States) (US)

Publication Details

Journal: Journal of Medicinal Chemistry
Published: 2026-03-31
DOI: https://doi.org/10.1021/acs.jmedchem.6c00514
Primary Topic: Fibroblast Growth Factor Research
Type: article
Field-Weighted Citation Impact: 0.00

Controls

|||

ALL TIME

JAN

FEB

MAR

APR

MAY

JUN

JUL

AUG

SEP

OCT

article

Structure-Based Design of a Novel Covalent 4-(1-Methylindol-3-yl)pyrimidin-2-amine Series Targeting FGFR2 Resistance Mutations

Samhita Iyer, Jacqueline H. Starrett, Isaac Hoffman, Kirk Nelson et al.

Mar 31, 2026

Journal of Medicinal Chemistry

Fibroblast Growth Factor Research

article

Structure-Based Design of a Novel Covalent 4-(1-Methylindol-3-yl)pyrimidin-2-amine Series Targeting FGFR2 Resistance Mutations

Samhita Iyer, Jacqueline H. Starrett, Isaac Hoffman, Kirk Nelson, Alexandra Balcer, Melissa Neal, Ronald V. Swanson, Robert L. Hudkins, Daniel C. Bensen, Qing Ye, Todd J. Harris, Marc Rideout, Eric Allen, Caleb B. Frye

March 31, 2026article en

Abstract

No abstract available for this paper.

Journal of Medicinal ChemistryVol. 69(7)

State Street (United States) (US), Nanospectra Biosciences (United States) (US)

Good health and well-being

Openalex Percentile: Top 31%

Fibroblast Growth Factor Research

DOI Source OpenAlex

AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.