Effects of whole cycle nutrition management based on “Hospital to Home (H2H)” model on nutritional status and immune function of patients with gastrointestinal tumor chemotherapy

Aim: To evaluate effects of whole-cycle nutrition management based on "Hospital to Home (H2H)" model on nutritional status and immune function in gastric and colorectal cancer patients receiving chemotherapy. Methods: = 50). Primary outcomes were PG-SGA score and serum albumin. Secondary outcomes included immune function (CD4+, CD8 + counts, CD4+/CD8 + ratio), hematological parameters, cancer-related fatigue (PFS), self-care ability (ESCA), quality of life (GQOLI-74), adverse reactions (CTCAE 5.0), and nursing satisfaction. Linear mixed-effects models with FDR correction were used for repeated measures. Results: = 0.01) in the study group. Conclusion: H2H whole-cycle nutrition management improves nutritional status, immune function, fatigue, self-care ability, quality of life, and satisfaction while reducing adverse reactions in gastric and colorectal cancer patients receiving chemotherapy. Larger multicenter studies with long-term follow-up are needed to confirm these findings and assess survival outcomes.