Comparative Efficacy of Methotrexate Versus Cyclosporine in the Treatment of Moderate-to-Severe Chronic Plaque Psoriasis: A Systematic Review and Meta-Analysis
= .10) showed no difference between the 2 treatments, but the difference was not statistically significant. In terms of safety, methotrexate had fewer adverse events overall but was more associated with elevated liver enzymes (RR = 13.35). Methotrexate and cyclosporine show comparable efficacy in moderate-to-severe psoriasis, though methotrexate has a more favorable safety profile.
Authors
- Abdul Wali Khan (ORCID: https://orcid.org/0000-0002-5450-930X)
- Urwah Noor (ORCID: https://orcid.org/0009-0007-3885-5898)
- Sameen Mukhtar (ORCID: https://orcid.org/0009-0008-7405-0170)
- Hussain Haider Shah (ORCID: https://orcid.org/0000-0002-8032-7462)
- Muhammad Hanzalah Atif
- Areeba Hanif (ORCID: https://orcid.org/0009-0004-9659-2764)
- Hadia Rehman
- Hira Javed
- Muhammad Shumas
- Unsa Ali
- Mahnoor Zafar
Institutions
- Karachi Medical and Dental College (PK)
- CMH Lahore Medical College and Institute of Dentistry (PK)
- Farooq Hospital (PK)
- Dow University of Health Sciences (PK)
- Rahnuma (PK)
Publication Details
- Journal
- Journal of Cutaneous Medicine and Surgery
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1177/12034754261431774
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00