Single-molecule dynamics reveal ATP binding alone powers substrate translocation by an ABC transporter
-dependent ATP hydrolysis is required to reset the transporter. These findings establish a direct mechanistic link between ATP binding and substrate translocation at single-molecule resolution and provide insight into the catalytic cycle of ABC transporters.
Authors
- Robert Tampé (ORCID: https://orcid.org/0000-0002-0403-2160)
- Tobias Nocker
- Lukas Sušac
- Matija Pečak
- Amin Fahim (ORCID: https://orcid.org/0009-0008-7529-9592)
- Christoph Nocker
Institutions
- Goethe University Frankfurt (DE)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1038/s41467-026-70021-1
- Citations
- 1
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 14.99
Funders
- Deutsche Forschungsgemeinschaft
- Rijksuniversiteit Groningen