Serum Levels of Glutamatergic (GRIN1) and Purinergic (P2RX1/P2RY2) Receptors in Patients with Fibromyalgia

< 0.001 for all). At optimal cut-off values, GRIN1, P2RX1, and P2RY2 showed sensitivities of 91.4%, 78.5%, and 92.5%, and specificities of 72.00%, 75.3%, and 80.6%, respectively. Serum GRIN1, P2RX1, and P2RY2 levels exhibit strong diagnostic performance in FM and may serve as promising biomarkers reflecting altered glutamatergic and purinergic signaling in disease pathophysiology.

Authors

Zuhal Tunçbilek (ORCID: https://orcid.org/0000-0002-6510-0884)
Ayça Taş (ORCID: https://orcid.org/0000-0002-7132-1325)
Sevil Ceyhan Doğan (ORCID: https://orcid.org/0000-0003-1570-8848)
Mert Atas (ORCID: https://orcid.org/0000-0002-6713-5888)
Gülcihan Cinar Kaya

Institutions

Sivas Cumhuriyet Üniversitesi (TR)

Publication Details

Journal: International Journal of Molecular Sciences
Published: 2026-03-31
DOI: https://doi.org/10.3390/ijms27073164
Primary Topic: Adenosine and Purinergic Signaling
Type: article
Field-Weighted Citation Impact: 0.00

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article

Serum Levels of Glutamatergic (GRIN1) and Purinergic (P2RX1/P2RY2) Receptors in Patients with Fibromyalgia

Zuhal Tunçbilek, Ayça Taş, Sevil Ceyhan Doğan, Mert Atas et al.

Mar 31, 2026

International Journal of Molecular Sciences

Adenosine and Purinergic Signaling

article

Serum Levels of Glutamatergic (GRIN1) and Purinergic (P2RX1/P2RY2) Receptors in Patients with Fibromyalgia

Zuhal Tunçbilek, Ayça Taş, Sevil Ceyhan Doğan, Mert Atas, Gülcihan Cinar Kaya

March 31, 2026article en

Abstract

< 0.001 for all). At optimal cut-off values, GRIN1, P2RX1, and P2RY2 showed sensitivities of 91.4%, 78.5%, and 92.5%, and specificities of 72.00%, 75.3%, and 80.6%, respectively. Serum GRIN1, P2RX1, and P2RY2 levels exhibit strong diagnostic performance in FM and may serve as promising biomarkers reflecting altered glutamatergic and purinergic signaling in disease pathophysiology.

International Journal of Molecular SciencesVol. 27(7)

Sivas Cumhuriyet Üniversitesi (TR)

Good health and well-being

Openalex Percentile: Top 30%

Adenosine and Purinergic Signaling

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