Formation and persistence of estragole-derived DNA adducts in human liver cells and tissue
-dG adducts in human liver cells, however at lower levels than expected. Altogether, this study demonstrated the occurrence of ES-derived DNA adducts in human liver tissue at levels comparable to the structurally related methyleugenol. Notably, the found DNA adduct levels are well below those reported to cause mutagenicity and clastogenicity in human cells and rodent in vivo models.
Authors
- D. Schrenk
- G. Manolikakes
- S. Stegmüller
- J. H. Küpper
- M. Christmann
- M. Abel-Beckmann
- J. Fahrer
- E. Richling
- C. Quarz
- M. Halaczkiewicz
- G. Ackermann
Institutions
- University of Kaiserslautern (DE)
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Brandenburg University of Technology Cottbus-Senftenberg (DE)
Publication Details
- Journal
- Archives of Toxicology
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1007/s00204-026-04364-5
- Primary Topic
- Carcinogens and Genotoxicity Assessment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau
- Deutsche Forschungsgemeinschaft