Anti-fibrotic effect of Spirulina maxima-derived extracellular vesicles: possible role of PARK7 and HSP70 chaperones
Introduction: exhibit antifibrotic activity. Methods: _sEV was further investigated in a chlorhexidine digluconate (CG)-induced mouse model of peritoneal fibrosis. Results: _sEVs reduced CG-induced submesothelial thickening, fibronectin, and collagen type I alpha 1 immunopositivity, and increased cytokeratin 18, immunopositivity in the mesothelial layer. Discussion: _sEV and support their further investigation in the context of fibrosis.
Authors
- Domonkos Pap (ORCID: https://orcid.org/0000-0002-1718-1210)
- Csenge Szász
- Beáta Szebeni (ORCID: https://orcid.org/0000-0001-7577-9803)
- Zoltán Molnár (ORCID: https://orcid.org/0000-0003-2345-3611)
- Ádám Vannay (ORCID: https://orcid.org/0000-0001-7412-4733)
- Tamás Mészáros (ORCID: https://orcid.org/0000-0002-7396-9678)
- A. J. Szabo
- Apor Veres-Székely (ORCID: https://orcid.org/0000-0002-6830-8779)
- Marcell Pálmai (ORCID: https://orcid.org/0000-0001-9348-0733)
- Mária Bernáth
- Tamás Visnovitz (ORCID: https://orcid.org/0000-0002-7962-5083)
- Dorina Lenzinger (ORCID: https://orcid.org/0000-0003-0270-7985)
- Péter Bokrossy (ORCID: https://orcid.org/0009-0005-5509-1557)
- E. Buzas
- Zoltán Varga
- Éva Pállinger
- Judith Mihály
- Nóra Fekete
Institutions
- Semmelweis University (HU)
- Eötvös Loránd University (HU)
- American Society of Nephrology (US)
- Budapest University of Technology and Economics (HU)
- Sergeev Institute of Environmental Geoscience (RU)
- Veroscience (United States) (US)
- HUN-REN Research Centre for Natural Sciences (HU)
- Széchenyi István University (HU)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2026-03-31
- DOI
- https://doi.org/10.3389/fbioe.2026.1761403
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Magyar Tudományos Akadémia