Development and Internal Validation of an MRI-Based Diagnostic Prediction Model for Differentiating Cystic Pituitary Adenoma and Rathke’s Cleft Cyst

: The proposed MRI-based multivariable prediction model demonstrated high discrimination and provides a structured approach for estimating the probability of cystic pituitary adenoma using routinely available MRI features. Such an approach may help reduce unnecessary surgical interventions in patients with Rathke's cleft cyst while facilitating appropriate treatment planning for cystic pituitary adenomas. However, external validation in larger cohorts is required before routine clinical implementation.