Individual gray–white matter functional connection predicts tau spread and cognitive decline in Alzheimer’s disease

PURPOSE: and tau deposition and to evaluate its value in predicting longitudinal tau spread. METHODS: and tau deposition and then constructed an individual-level spreading model to predict longitudinal tau accumulation. RESULTS: showed a positive correlation with tau deposition. Model-simulated white-matter tau deposition was associated with clinical scales and predicted cognitive decline. The spreading model, which incorporated baseline tau-PET and the top 10% of gray and white matter, yielded the highest predictive performance for future tau accumulation. CONCLUSION: in understanding tau propagation and support development of network-targeted therapeutic strategies.