Discovering novel therapeutic VHHs for emerging viruses: perspectives from VEEV selection strategies
Introduction: Hs). Methods: Hs using phage and yeast display methodology with three antigen formats 1) recombinant E2, 2) linear peptides of E2, selected based on molecular dynamics analysis, and 3) UV inactivated virus. Results: Hs. Discussion: Hs to perform viral "sponging" which represents a novel therapeutic approach. The selection strategies we report may have applications to further antibody developments against other viruses.
Authors
- Nileena Velappan
- Jennifer M. Zupancic
- Alison M. Kell (ORCID: https://orcid.org/0000-0001-5550-1038)
- Fortunato Ferrara
- Alba L. Montoya (ORCID: https://orcid.org/0000-0002-1803-1564)
- Autumn T. LaPointe
- Li-Wei Hung
- Jurgen Schmidt
Institutions
- Los Alamos National Laboratory (US)
- University of New Mexico (US)
- Specifica (United States) (US)
- Bioscience (Slovakia) (SK)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-31
- DOI
- https://doi.org/10.3389/fimmu.2026.1806908
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Defense Threat Reduction Agency
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases
- Los Alamos National Laboratory