Functional analysis of the <i>rv1371/2/3</i> operon in mycobacteria
allele, which leads to the differential phenotype observed in macrophage infection and SDS resistance assays. IMPORTANCE: and the attenuated BCG vaccine, providing a model to study how lipid-driven manipulation of host cells alters infection outcomes. Consequently, this operon and its products emerge as potential targets for therapeutic development aimed at disrupting the bacterial mechanisms associated with critical events that culminate in successful infection.
Authors
- Paloma Rezende Corrêa
- Livia C. Barbosa (ORCID: https://orcid.org/0000-0001-6020-0117)
- Philip Noël Suffys (ORCID: https://orcid.org/0000-0001-8527-9300)
- Meydson Benjamim Carvalho Corrêa (ORCID: https://orcid.org/0000-0002-9865-9457)
- Antônio José da Silva Gonçalves
- Christophe Guilhot (ORCID: https://orcid.org/0000-0002-8052-4685)
- Wladimir Malaga
- Marcos Gustavo Araujo Schwarz (ORCID: https://orcid.org/0000-0002-6858-0860)
- Leila Mendonça-Lima
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Centre National de la Recherche Scientifique (FR)
- Faculdades Oswaldo Cruz (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1128/spectrum.03596-25
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00