Roseburia-Associated Gut–Brain Axis Alterations in Relapsing–Remitting Multiple Sclerosis: Evidence from a Household-Matched Case–Control Study
RRMS and greater disease severity are associated with gut microbial alterations characterized by reduced SCFA-producing bacteria. Despite limitations including small sample size and sex imbalance, the household-matched design strengthens internal validity. Our findings highlight the potential of targeting the gut microbiota, an accessible compartment within the gut-brain axis, for MS management.
Authors
- Silvia Ancona (ORCID: https://orcid.org/0000-0003-1999-129X)
- Emerenziana Ottaviano (ORCID: https://orcid.org/0000-0003-3839-2698)
- Alen Zollo (ORCID: https://orcid.org/0009-0005-0908-7469)
- Alessandra Mingione (ORCID: https://orcid.org/0000-0001-8008-0191)
- Maria Laura Terzi Mazzieri
- Matteo Domenico Marsiglia (ORCID: https://orcid.org/0009-0009-3421-9223)
- Andrea Corona
- Elisa Borghi
- Filippo Martinelli Boneschi
- Alberto Priori
Institutions
- AOL (United States) (US)
- University of Milan (IT)
- Ospedale San Paolo (IT)
Publication Details
- Journal
- Nutrients
- Published
- 2026-03-31
- DOI
- https://doi.org/10.3390/nu18071117
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00