<i>Enterobacter roggenkampii</i> ST422 with highly conjugative IncP plasmid carrying <i>bla</i> <sub>KPC-2</sub> gene from Lebanon: a case report
Background: complex (ECC) includes opportunistic pathogens that can be carbapenem resistant, thus complicating treatment regimens. Here, we characterized a carbapenem- and colistin-resistant ECC O89H7 isolate expressing KPC carbapenemase. Case Summary: on a mobilizable IncP-6 plasmid of 51 kb, as revealed by mating-out assays. Conclusion: O89H7 represents a major health threat due to limited therapeutic options, especially because novel β-lactam/inhibitor combinations are not available in Lebanon. Our results highlight an urgent need for improved carbapenemase screening and detection capacity in clinical laboratories and for enhanced genomic surveillance of MDR bacteria to implement intervention strategies to control their spread in Lebanon and beyond.
Authors
- Delphine Girlich (ORCID: https://orcid.org/0000-0002-7698-2798)
- Bogdan Iuliu Iorga (ORCID: https://orcid.org/0000-0003-0392-1350)
- Saoussen Oueslati (ORCID: https://orcid.org/0000-0001-5766-3831)
- Hassan Mallat (ORCID: https://orcid.org/0000-0002-5358-4148)
- Issmat I. Kassem (ORCID: https://orcid.org/0000-0002-2978-9573)
- Dina Daaboul (ORCID: https://orcid.org/0009-0005-4830-5019)
- Souad Fayad
- Marwan Osman
- Thierry Naas
- Fouad Dabboussi
- Monzer Hamze
- Laurent Dortet
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut de Chimie des Substances Naturelles (FR)
- Inserm (FR)
- Lebanese University (LB)
- University of Georgia (US)
- Holy Spirit University of Kaslik (LB)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Yale University (US)
- Laboratoire National de Référence (MA)
- CEA Paris-Saclay (FR)
- Nini Hospital (LB)
- Bicêtre Hospital (FR)
- American University of Beirut (LB)
Publication Details
- Journal
- ASM Case Reports
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1128/asmcr.00239-25
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Assistance Publique - Hôpitaux de Paris
- Université Paris-Saclay