Quaternary Phosphonium Salts Outperformed Vemurafenib (PLX) and Etoposide Against BRAFV600D,V600E PLX-Resistant Melanoma and MDR Neuroblastoma, Exhibiting No/Low Toxicity on 3T3/HaCaT Cells

could be used to develop 24 and 48 h treatments for PLX-R MeTRAV cells. Also, all compounds could be developed as new treatment options for both ETO-sensitive and MDR late-stage HR-NB cells, being even more effective than ETO by 1.2, 2.0, and 1.3 times (HTLA 230) and 3.2, 4.7, and 3.2 times (HTLA ER). All compounds have the potential to be developed as adjuvants in already existing anticancer cocktails to treat MCM and/or NB.

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Publication Details

Journal
International Journal of Molecular Sciences
Published
2026-03-31
DOI
https://doi.org/10.3390/ijms27073170
Primary Topic
Melanoma and MAPK Pathways
Type
article
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article

Quaternary Phosphonium Salts Outperformed Vemurafenib (PLX) and Etoposide Against BRAFV600D,V600E PLX-Resistant Melanoma and MDR Neuroblastoma, Exhibiting No/Low Toxicity on 3T3/HaCaT Cells

Maria Grazia Signorello, Cinzia Domenicotti, Barbara Marengo, Sara Tirendi et al.
International Journal of Molecular Sciences
Melanoma and MAPK Pathways
article

Quaternary Phosphonium Salts Outperformed Vemurafenib (PLX) and Etoposide Against BRAFV600D,V600E PLX-Resistant Melanoma and MDR Neuroblastoma, Exhibiting No/Low Toxicity on 3T3/HaCaT Cells

Maria Grazia Signorello, Cinzia Domenicotti, Barbara Marengo, Sara Tirendi, Silvana Alfei, Elaheh Khaledizadeh, Paolo Giordani, Caterina Reggio
article en

Abstract

could be used to develop 24 and 48 h treatments for PLX-R MeTRAV cells. Also, all compounds could be developed as new treatment options for both ETO-sensitive and MDR late-stage HR-NB cells, being even more effective than ETO by 1.2, 2.0, and 1.3 times (HTLA 230) and 3.2, 4.7, and 3.2 times (HTLA ER). All compounds have the potential to be developed as adjuvants in already existing anticancer cocktails to treat MCM and/or NB.

International Journal of Molecular SciencesVol. 27(7)
University of Pisa (IT), Istituto Giannina Gaslini (IT), Azienda Ospedaliera S.Maria (IT), University of Genoa (IT)
Good health and well-being
Openalex Percentile: Top 35%
Melanoma and MAPK Pathways
DOIOpen Access PDFOpenAlex
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Quaternary Phosphonium Salts Outperformed Vemurafenib (PLX) and Etoposide Against BRAFV600D,V600E PLX-Resistant Melanoma and MDR Neuroblastoma, Exhibiting No/Low Toxicity on 3T3/HaCaT Cells — Maria Grazia Signorello, Cinzia Domenicotti, et al. · International Journal of Molecular Sciences (2026) | TGRS Research Map | TGRS