SAR-Guided Scaffold Innovation of Selective V <sub>2</sub> R Antagonists: Therapeutic Frontiers in ADPKD

R antagonist analogues. Supported by multidimensional pharmacological evaluations, these findings provide an important framework for the rational design and optimization of next-generation therapeutics for ADPKD.

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Publication Details

Journal
ACS Medicinal Chemistry Letters
Published
2026-03-31
DOI
https://doi.org/10.1021/acsmedchemlett.6c00105
Primary Topic
Cellular transport and secretion
Type
article
Field-Weighted Citation Impact
0.00

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article

SAR-Guided Scaffold Innovation of Selective V 2 R Antagonists: Therapeutic Frontiers in ADPKD

Steven H. Liang, Haofeng Shi
ACS Medicinal Chemistry Letters
Cellular transport and secretion
article

SAR-Guided Scaffold Innovation of Selective V 2 R Antagonists: Therapeutic Frontiers in ADPKD

Steven H. Liang, Haofeng Shi
article en

Abstract

R antagonist analogues. Supported by multidimensional pharmacological evaluations, these findings provide an important framework for the rational design and optimization of next-generation therapeutics for ADPKD.

ACS Medicinal Chemistry LettersVol. 17(4)
Georgia Institute of Technology (US), Emory University (US), The Wallace H. Coulter Department of Biomedical Engineering (US)
Emory University, National Institutes of Health, School of Medicine, Emory University, All of Us Research Program
Industry, innovation and infrastructure
Openalex Percentile: Top 31%
Cellular transport and secretion
DOIOpen Access PDFOpenAlex
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SAR-Guided Scaffold Innovation of Selective V <sub>2</sub> R Antagonists: Therapeutic Frontiers in ADPKD — Steven H. Liang, Haofeng Shi · ACS Medicinal Chemistry Letters (2026) | TGRS Research Map | TGRS