Synthesis, Antifungal Evaluation, and Quantitative Structure–Activity Relationship of Camptothecin Derivatives against Phytopathogenic Fungi
exerts its antifungal effects through the inhibition of spore germination, disruption of hyphal morphology, impairment of cell wall and membrane integrity, and induction of reactive oxygen species accumulation. QSAR analysis further identified key mass/electronic descriptors governing activity, providing guidance for the rational optimization of CPT-based fungicides.
Authors
- Gongyuan Zhao (ORCID: https://orcid.org/0000-0002-4406-5426)
- Yuguo Wu
- Zhonghui Sun (ORCID: https://orcid.org/0009-0001-3473-3355)
- SiKai Di
- Jinsong Peng
- Chunxia Chen
- Jing Zhang
- Qing Li
Institutions
- Collins College (US)
- Culture Resource (EG)
- Innovative Research (United States) (US)
- Northeast Forestry University (CN)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1021/acs.jafc.5c13489
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities