Diet quality attenuates the association between flavonoid intake and hepatic steatosis risk in the Framingham Heart Study
< 0·05), with up to 40 % reduced odds at the highest quartiles before adjustment for diet quality. After adjustments, associations attenuated and lost statistical significance. The attenuation does not rule out a potential protective role of flavonoids; it may indicate that higher flavonoid intake is an important element of a broader healthy diet. Alternatively, the associations could be confounded by other components of diet which may independently reduce steatosis risk. Nonetheless, these findings underscore the importance of promoting flavonoid-rich diets in the context of overall healthy diet and support further investigation in prospective and interventional studies targeting MASLD prevention.
Authors
- Vincent Gao (ORCID: https://orcid.org/0000-0002-1311-001X)
- Jiantao Ma
- Paul F. Jacques
Institutions
- Tufts University (US)
- University of Missouri (US)
Publication Details
- Journal
- British Journal Of Nutrition
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1017/s0007114526106825
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Agriculture
- National Institutes of Health
- Agricultural Research Service