Deletion of Alg13 disrupts postnatal development and migration of GABAergic cortical interneurons

Background: may play a critical role in cortical interneuron development. Methods: deletion on the distribution and migration of interneurons in the cerebral cortex of postnatal mice. Transcriptome sequencing was performed to identify genes involved in neuronal development, and the findings were validated using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Results: , that were associated with the development of inhibitory interneurons. Conclusion: -associated refractory seizures, thereby advancing knowledge of interneuron developmental regulation.