Molecularly Imprinted Aggregation-Induced Electrochemiluminescence Interface Based on Quinoline-Malononitrile Nanomaterials for Specific and Ultrasensitive Recognition of Zearalenone

, providing a bright and stable transduction platform. An electropolymerized imprinting layer was then constructed in the presence of ZEN and subsequently eluted to generate specific binding cavities, leading to a characteristic "decrease-recovery-decrease" ECL evolution during film growth, template removal, and target rebinding. Under optimized conditions, ZEN induced pronounced ECL quenching with a good linear response from 0.01 to 100 ng/mL and a detection limit of 7.24 pg/mL. The sensor also showed excellent reproducibility and operational stability, and achieved satisfactory recoveries in corn flour, wheat flour, and beer samples. Collectively, this work demonstrates an effective strategy to integrate bright AIECL organic emitters with robust MIP recognition for selective and sensitive ZEN monitoring in complex food matrices.

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Publication Details

Journal
Analytical Chemistry
Published
2026-03-31
DOI
https://doi.org/10.1021/acs.analchem.6c01356
Primary Topic
Advanced biosensing and bioanalysis techniques
Type
article
Field-Weighted Citation Impact
0.00

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article

Molecularly Imprinted Aggregation-Induced Electrochemiluminescence Interface Based on Quinoline-Malononitrile Nanomaterials for Specific and Ultrasensitive Recognition of Zearalenone

Peiyao Du, Shaoyu Zou, Meluze Luobu, Xiaoquan Lu et al.
Analytical Chemistry
Advanced biosensing and bioanalysis techniques
article

Molecularly Imprinted Aggregation-Induced Electrochemiluminescence Interface Based on Quinoline-Malononitrile Nanomaterials for Specific and Ultrasensitive Recognition of Zearalenone

Peiyao Du, Shaoyu Zou, Meluze Luobu, Xiaoquan Lu, Hui Xiao, Zhengang Han, Shuying Li
article en

Abstract

, providing a bright and stable transduction platform. An electropolymerized imprinting layer was then constructed in the presence of ZEN and subsequently eluted to generate specific binding cavities, leading to a characteristic "decrease-recovery-decrease" ECL evolution during film growth, template removal, and target rebinding. Under optimized conditions, ZEN induced pronounced ECL quenching with a good linear response from 0.01 to 100 ng/mL and a detection limit of 7.24 pg/mL. The sensor also showed excellent reproducibility and operational stability, and achieved satisfactory recoveries in corn flour, wheat flour, and beer samples. Collectively, this work demonstrates an effective strategy to integrate bright AIECL organic emitters with robust MIP recognition for selective and sensitive ZEN monitoring in complex food matrices.

Analytical ChemistryVol. 98(14)
Northwest Normal University (CN), Northwest A&F University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 35%
Advanced biosensing and bioanalysis techniques
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Molecularly Imprinted Aggregation-Induced Electrochemiluminescence Interface Based on Quinoline-Malononitrile Nanomaterials for Specific and Ultrasensitive Recognition of Zearalenone — Peiyao Du, Shaoyu Zou, et al. · Analytical Chemistry (2026) | TGRS Research Map | TGRS