CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

CRISPR-Cas9 genome-wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening. With contemporary evidence increasingly highlighting the differences in biology between adult and children's cancers, more research has gradually occurred investigating dependencies and mechanisms of resistance in paediatric cancers through the use of CRISPR-Cas9 genome-wide screens. This review collates and summarises the experimental genome-wide screens that have been performed specifically in paediatric cancer models, and highlights the versatility of this technology and the knowledge gained through this research.