Protective association of the HIF-1α rs11549465 polymorphism with metabolic syndrome in people living with HIV on antiretroviral therapy
Background: rs11549465 polymorphism and MS in PLWH on ART. Methods: rs11549465 polymorphism was performed using Real-time PCR with a TaqMan assay. Clinical, metabolic, and HIV-related parameters were analysed. Multivariable logistic regression was used to identify independent factors associated with MS. Results: < 0.05). Conclusion: rs11549465 T allele and CT+TT genotypes are associated with a lower odds of prevalent MS and hypertension in PLWH receiving ART. This protective association remained evident after adjustment for established metabolic risk factors, although it appeared less pronounced with longer HIV infection and ART duration.
Authors
- Ivana Gmizic
- Biljana Ljujić (ORCID: https://orcid.org/0000-0002-6759-2720)
- Nataša Minić (ORCID: https://orcid.org/0009-0007-0347-0592)
- Ivan Rajkovic
- Jovana Ranin
- Jovan Ranin (ORCID: https://orcid.org/0000-0003-0398-9486)
- Ivana Lesnjak (ORCID: https://orcid.org/0009-0007-0011-5704)
- Marko Marković (ORCID: https://orcid.org/0009-0002-3574-3341)
- Biljana Popovska Jovičić
- Nemanja Đorđević
- Marina Kostić
Institutions
- University of Kragujevac (RS)
- University of Belgrade (RS)
- University Clinical Centre (PL)
- Clinical Centre of Kragujevac (RS)
- Hospital for Tropical Diseases (VN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-03-31
- DOI
- https://doi.org/10.3389/fmed.2026.1802450
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu