Integrated Single-Cell and Spatial Multi-Omics of Clonal Precursors and Immune Niches in Germinal Center Lymphomas
: This work demonstrates the feasibility of integrating single-cell and spatial analyses in GC lymphomas and provides a framework for investigating tumor heterogeneity and immune organization. These findings may inform future studies on biomarker development and the rational design of immunotherapies.
Authors
- Carlos Grande (ORCID: https://orcid.org/0000-0001-7227-1975)
- A. Alfonso
- Sarai Sarvide (ORCID: https://orcid.org/0000-0003-3528-9329)
- Ramón Robledano (ORCID: https://orcid.org/0009-0001-3524-9020)
- Diego Alignani (ORCID: https://orcid.org/0000-0003-0241-1375)
- Miguel Canales (ORCID: https://orcid.org/0000-0002-6550-2621)
- Teresa Ezponda (ORCID: https://orcid.org/0000-0003-3682-7125)
- Patxi San Martín‐Úriz (ORCID: https://orcid.org/0000-0003-1483-4279)
- Esther Pena (ORCID: https://orcid.org/0000-0001-5979-064X)
- Beñat Ariceta (ORCID: https://orcid.org/0000-0001-8819-402X)
- Aitziber Lopez Lopez
- Amaia Amaia Vilas-Zornoza
- Sergio Roa
- Santiago Browne
- Felipe Prósper
- Paula Aguirre-Ruiz
- Alvaro Lopez-Janeiro
- Jose Ángel Martínez-Climent
- Rocío Figueroa
- Sofía Huerga-Domínguez
Institutions
- Navarre Institute of Health Research (ES)
- Clinica Universidad de Navarra (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
Publication Details
- Journal
- Cancers
- Published
- 2026-03-31
- DOI
- https://doi.org/10.3390/cancers18071122
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad de Navarra
- Centro de Investigación Biomédica en Red de Cáncer
- Instituto de Salud Carlos III