Genomic evidence of convergence of multidrug resistance and enhanced virulence in carbapenem- and colistin-resistant <i>Klebsiella pneumoniae</i> from Turkey

isolates, revealing the frequent convergence of antimicrobial resistance and genetic signatures indicative of enhanced virulence in these strains. Notably, most isolates belonged to ST2096, clustering with genomes from Turkey and other countries, highlighting the international spread of these high-risk clones. The emergence of these difficult-to-treat pathogens emphasizes the urgent need for targeted action, including sustained genomic surveillance, stronger infection prevention, and improved antimicrobial stewardship. Policymakers, clinicians, and public health stakeholders must collaborate to enhance diagnostic capacity, surveillance systems, and infection control, particularly in countries where existing gaps exacerbate the spread of multidrug-resistant pathogens with high-virulence genotypes.

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Publication Details

Journal
Microbiology Spectrum
Published
2026-03-31
DOI
https://doi.org/10.1128/spectrum.03393-25
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
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article

Genomic evidence of convergence of multidrug resistance and enhanced virulence in carbapenem- and colistin-resistant Klebsiella pneumoniae from Turkey

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Genomic evidence of convergence of multidrug resistance and enhanced virulence in carbapenem- and colistin-resistant Klebsiella pneumoniae from Turkey

Steven J. Schiff, Jouman W. Hassan, Anahita Ghorbani Tajani, Issmat I. Kassem, Bledar Bisha, Jessica E. Ericson, Rayane Rafei, Mehmet Özdemir, Marwan Osman, M Doğan, Amine Baroudi, Hasna Abbass, Fouad Dabboussi, Monzer Hamze
article en

Abstract

isolates, revealing the frequent convergence of antimicrobial resistance and genetic signatures indicative of enhanced virulence in these strains. Notably, most isolates belonged to ST2096, clustering with genomes from Turkey and other countries, highlighting the international spread of these high-risk clones. The emergence of these difficult-to-treat pathogens emphasizes the urgent need for targeted action, including sustained genomic surveillance, stronger infection prevention, and improved antimicrobial stewardship. Policymakers, clinicians, and public health stakeholders must collaborate to enhance diagnostic capacity, surveillance systems, and infection control, particularly in countries where existing gaps exacerbate the spread of multidrug-resistant pathogens with high-virulence genotypes.

Microbiology SpectrumVol. 14(5)
University of Wyoming (US), Center for Food Safety and Applied Nutrition (US), Pennsylvania State University (US), Lebanese University (LB), Yale University (US), Necmettin Erbakan University (TR), Nini Hospital (LB), American University of Beirut (LB)
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Openalex Percentile: Top 41%
Antibiotic Resistance in Bacteria
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