Differential Effects of Oleoyl Serine and HU-910 on Anxiety-like and Depression-like Behaviors in Male and Female WKY Rats
)) in males. Exploratory in silico absorption, distribution, metabolism, and excretion (ADME) profiling suggests that sex-dependent pharmacokinetic variability may partly underlie the observed behavioral differences, in addition to possible pharmacodynamic factors. Our study provides a lead towards unraveling the putative sex differences in response to both conventional antidepressants (e.g., IMI) and emerging pharmacological agents (e.g., OS, HU-910). Further, our study helps advance the field of neuropharmacology by elucidating the anxiolytic-like and antidepressant-like effects of OS and HU-910.
Authors
- Gal Shoval (ORCID: https://orcid.org/0000-0003-1034-3640)
- Aron Weller (ORCID: https://orcid.org/0000-0002-0663-4384)
- Natalya M. Kogan (ORCID: https://orcid.org/0000-0002-6792-3841)
- Lee Koren (ORCID: https://orcid.org/0000-0002-7425-501X)
- Devorah Matas
- Gil Zalsman (ORCID: https://orcid.org/0000-0003-2269-2928)
- Igor Koman (ORCID: https://orcid.org/0000-0002-4860-9830)
- Elin Kachuki Dory
- Natalia Zemliana
- Yoni Loterstein
- E Sharon
- Jenna Gellman
Institutions
- Bar-Ilan University (IL)
- Tel Aviv University (IL)
- Geha Mental Health Center (IL)
- Ariel University (IL)
- Columbia University (US)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-03-31
- DOI
- https://doi.org/10.3390/ijms27073177
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bar-Ilan University