Ectopic action potentials in regular spiking neurons in the anesthetized mouse

Ectopic action potentials (EAPs) are elicited in distal axons by elevated neuronal activity and can propagate to remote terminals. EAPs are found in both normal and pathological tissue. Although studies show their occurrence in inhibitory interneurons both in vitro and in vivo, EAPs are only known to be found in pyramidal neurons in acute slices. Here, we demonstrate their existence for the first time in layer 2/3 regular spiking neurons in the anesthetized mouse.