Secreted factors of <i>Staphylococcus aureus</i> promote co-invasion with <i>Candida albicans</i> by inducing hypha formation and invasion
hypha extension through the production of, presently unknown, secreted factors and sequentially using hypha proteins Als1p and Als3p to bind to the hyphae and co-invade. These insights are important from a microbial ecological perspective and offer important potential targets for interfering with the interaction and reducing the virulence of these opportunistic pathogens.
Authors
- Stanley Brul (ORCID: https://orcid.org/0000-0001-5706-8768)
- Sebastian A. J. Zaat (ORCID: https://orcid.org/0000-0001-9589-186X)
- Raymond Pasman
- Bastiaan P. Krom (ORCID: https://orcid.org/0000-0002-1497-1161)
Institutions
- Amsterdam UMC Location University of Amsterdam (NL)
- Academic Center for Dentistry Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- Stichting Wetenschappelijk Onderzoek Verkeersveiligheid (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Applied and Environmental Microbiology
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1128/aem.01961-25
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00