Purulent meningitis in X-linked agammaglobulinemia: one case report

X-linked agammaglobulinemia (XLA) is characterized by a triad of primary immunodeficiency, profound hypogammaglobulinemia due to absent antibody production, and a consequent predisposition to severe and recurrent bacterial infections. We employed next-generation sequencing (NGS) on patients with immunodeficiency and their immediate relatives to facilitate the diagnosis and genetic counseling of XLA, thereby improving our understanding of this rare disorder.