Incontinentia Pigmenti With Neonatal Encephalopathy: A Case Report and Literature Review

gene. Although corticosteroid therapy was not initiated immediately, it was later introduced during infancy in response to electrographic hypsarrhythmia, resulting in successful resolution. Additionally, we conducted a retrospective review of the timing of seizure onset and the use of systemic corticosteroids as reported in the literature.ConclusionEarly clinical evaluation for central nervous system involvement is crucial in patients with IP. Given the genetic predisposition to neonatal encephalopathy and acute symptomatic seizures, symptomatic management with antiseizure medications is often required. Although no randomized clinical trials have been conducted, early immunotherapy with corticosteroids may be a viable option for managing acute neurologic complications. This report aims to promote early recognition of IP-associated neonatal encephalopathy, support timely intervention, and inform long-term follow-up strategies.