Plasma and parasternal subcutaneous tissue pharmacokinetics of ceftaroline fosamil in cardiac surgery with cardiopulmonary bypass

ranged from 93% to 99% with intermittent and 75%-86% during continuous administration. These findings demonstrate that ceftaroline penetration into subcutaneous parasternal tissue is highly variable in cardiac surgery patients and may limit tissue exposure under perioperative conditions despite favorable plasma concentrations. While continuous infusion improves plasma exposure, this does not necessarily translate into superior tissue exposure. Therefore, measurement of tissue concentrations is important when evaluating antibiotic dosing strategies in the perioperative setting.