The impact of the Lab4 probiotic on neurodegenerative processes in a murine Alzheimer’s disease model

Introduction: and, here, we have investigated its impact on aspects of neurodegeneration in the 3xTg Alzheimer's disease (AD) murine model. Method: Male 3xTg-AD mice were fed a high fat diet (to accelerate neurodegeneration) with or without daily Lab4 probiotic supplementation for 84 days. Endpoints included hippocampal neuronal spine density, novel object recognition, whole-brain gene expression, plasma cytokines/lipids, body weight, and faecal microbiota composition. Results: in probiotic-supplemented mice, alongside reduced numbers of viable yeast. Discussion: These preliminary findings highlight a neuroprotective impact in 3xTg-AD mice receiving the Lab4 probiotic and warrant more extensive assessments in murine models and/or human subjects.