Efficient synthesis of azoxystrobin and its key intermediate using a newer DABCO-based catalyst

A simple, convenient, and commercially feasible synthesis method has been developed for the synthesis of azoxystrobin and its intermediate using a DABCO-based catalyst. The methodology, which starts with coumaranone, uses a single catalyst for the two-step process, demonstrating high potential for industrial application. The catalyst synthesis and optimal catalyst concentration have been optimized to achieve maximum yield in the synthesis of the intermediate as well as technical azoxystrobin. The intermediate and final products, as well as the catalyst, were characterized by melting point, 1H NMR, 13C NMR, and high-resolution mass spectrometry. The HRMS analysis data supported the molecular formulae of the synthesized catalyst and product, showing the fragments m/z 143.1188 (M+H), C7H14N2O and 404.1262 (M+H), C22H17N3O5. The newer catalyst has the merits of being inexpensive, highly reactive, and environmentally friendly. The yield reached a high level, and this method can be considered a promising catalyst for the industrial-scale production of azoxystrobin and its key intermediate.