Biomimetic Microenvironment Nanomodulators for Reactive Oxygen Species-Responsive T <sub>1</sub> -T <sub>2</sub> Dual-Modal Magnetic Resonance Imaging and Visualized Treatment of Atherosclerosis
signals in plaques. Therapeutically, FeMn/Cur@CM multifacetedly modulates the plaque microenvironment by alleviating oxidative stress, neutralizing protons, promoting macrophage reprogramming, and restoring macrophage efferocytosis. As a result, the integrated theranostic platform demonstrates remarkable plaque regression and simultaneously realizes real-time visualization of lesion progression via dual-modal MRI, providing precise diagnosis of plaque milieu. Through inflammation-targeted intervention coupled with real-time imaging feedback, this biomimetic nanomodulator establishes a promising strategy for the precise treatment of inflammatory vascular diseases, offering translational potential for AS management.
Authors
- Mingkang Wang (ORCID: https://orcid.org/0009-0000-3119-5320)
- W.P. Zhu (ORCID: https://orcid.org/0000-0001-8379-2282)
- Runjianya Ling (ORCID: https://orcid.org/0000-0002-1185-6918)
- Xin Liu (ORCID: https://orcid.org/0000-0002-2561-9809)
- Zejian Wang (ORCID: https://orcid.org/0000-0002-9024-509X)
- Xiaohui Deng (ORCID: https://orcid.org/0000-0003-0030-439X)
- Tingting Yao
- Sunli Wan
- Yuehua Li
- Chuan Zhang
- Xinlong Liu
- Dan Wang
Institutions
- Shanghai Jiao Tong University (CN)
- IS Instruments (United Kingdom) (GB)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- ACS Nano
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1021/acsnano.5c21630
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Science and Technology Commission of Shanghai Municipality
- Shanghai Jiao Tong University