Primary Bone Lymphoma: A Case Report

A 26-year-old woman presented with three months progressive right hip pain and difficult ambulation, which was subsequently diagnosed as germinal center–type diffuse large B-cell lymphoma in the right femoral head, neck and upper-midshaft region without any nodal or visceral lesions. Primary bone lymphoma (PBL) is an uncommon extranodal lymphoma representing approximately 1% of all lymphomas and 3–7% of malignant primary bone tumors. While it typically affects older adults, occurrences in younger patients are rare and may lead to delayed recognition. PBL may radiologically resemble benign bone disease, emphasizing the importance of clinical suspicion. Diagnosis requires multimodal evaluation, with chemoimmunotherapy remaining the primary treatment.