Lymphodepleting preconditioning impairs host antitumor immunity induced by adoptive T cell therapy in mouse models
T cells underlying durable antitumor immunity that is impaired by lymphodepleting preconditioning in mouse models, suggesting an underappreciated mechanism of ACT resistance.
Authors
- Vicente Saavedra
- Sofía Hidalgo
- Daniela Andrea García Malavé
- Vincenzo Borgna (ORCID: https://orcid.org/0000-0002-4023-6179)
- Álvaro Lladser (ORCID: https://orcid.org/0000-0002-5576-1478)
- Felipe Ardiles
- Diego Figueroa (ORCID: https://orcid.org/0000-0002-7003-9205)
- Juan Pablo Vega
- Manuel Varas-Godoy
- Felipe Gálvez-Cancino
- María Rosa Bono
- Andrés Hernández-Oliveras
- Catalina Bustamante
- Hugo Gonzalez
- Ximena López
- Fabiola Osorio
Institutions
- Universidad de Santiago de Chile (CL)
- University of California, San Francisco (US)
- San Sebastián University (CL)
- Hospital Barros Luco-Trudeau (CL)
- Fundación Ciencia and Vida (CL)
- Fundación Arturo López Pérez (CL)
- Immune Regulation (United Kingdom) (GB)
- University of Chile (CL)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1038/s41467-026-71082-y
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agencia Nacional de Investigación y Desarrollo