PHYTOCHEMICAL PROFILE AND PHARMACOLOGICAL MECHANISMS OF CALOTROPIS GIGANTEA (LINN.) FOR WOUND HEALING POTENTIAL

Wound occurs when the skin is disrupted by the any out source or sharp objects. There are type types of wounds, which is an acute wound and chronic wound. Acute wound is a type when the tissue is cut by knife or any sharp objects. Chronic wound types are referred as pressure or ulcer, which takes longer time than acute wound to cure. The wound healing has four different stages like Homeostasis, inflammation, proliferation and remodelling. Calotropis Gigantea, also known as Milkweed, the plant has been widely used in traditional medicine system to treat many aliments like wound healing, inflammation, scabies, spleen enlargement etc,. The study focuses on phytochemical and pharmacological activities of Calotropis Gigantea. Phytochemical investigation revealed that it has wide activities of flavonoids, alkaloids, glycosides, saponins and tannins from different parts of the plant like leaves, flowers, roots and barks. The pharmacological activity includes antimicrobial, cytotoxicity, antibacterial, anti-inflammation, anti-venom, antioxidant and wound healing. This article states that the Calotropis gigantea has significant therapeutic potential and may be a good source for the creation of new therapeutic drugs. However, to confirm its safety and effectiveness for contemporary medical applications, more clinical research and standardization studies are needed.