A prefrontal cortex-lateral hypothalamus circuit controls stress-driven increased food intake

neurons are required downstream mPFC targets for transforming stress into heightened fat intake. Overall, we identify the mPFC-LHA as a multi-branched network, indispensable for stress-eating.

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Publication Details

Journal
Nature Communications
Published
2026-03-31
DOI
https://doi.org/10.1038/s41467-026-71073-z
Primary Topic
Regulation of Appetite and Obesity
Type
article
Field-Weighted Citation Impact
0.00

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article

A prefrontal cortex-lateral hypothalamus circuit controls stress-driven increased food intake

Annemieke Benschop, R. B. Poorthuis, M. C. M. Luijendijk, R. A. H. Adan et al.
Nature Communications
Regulation of Appetite and Obesity
article

A prefrontal cortex-lateral hypothalamus circuit controls stress-driven increased food intake

Annemieke Benschop, R. B. Poorthuis, M. C. M. Luijendijk, R. A. H. Adan, K. L. Kooij, D. Riga, R. Haak, F. J. Meye, L. F. Supiot, I. G. Wolterink-Donselaar, A. S. J. Nicolson, W. Du
article en

Abstract

neurons are required downstream mPFC targets for transforming stress into heightened fat intake. Overall, we identify the mPFC-LHA as a multi-branched network, indispensable for stress-eating.

Nature Communications
Utrecht University (NL), University Medical Center Utrecht (NL), Cognitive Research (United States) (US)
Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Horizon 2020 Framework Programme
Zero hunger
Openalex Percentile: Top 39%
Regulation of Appetite and Obesity
DOIOpen Access PDFOpenAlex
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