EVOLVING CONCEPTS IN PCOS: DIAGNOSTIC INNOVATIONS AND NOVEL THERAPEUTIC STRATEGIES

Polycystic Ovary Syndrome (PCOS) is far more than a reproductive disorder; it is a complex endocrine and metabolic challenge affecting up to 13% of women worldwide. While traditionally viewed through the lens of fertility, modern clinical understanding now links PCOS to deep-rooted issues like insulin resistance, chronic inflammation, and emerging evidence of gut dysbiosis. This article describes the transition from "symptom management" to "precision medicine.” The article highlights how advanced diagnostic tools—such as high-sensitivity hormonal assays and AMH testing—are providing earlier, more accurate interventions. Furthermore, the shift in the therapeutic landscape has been examined, where traditional treatments are being bolstered by novel agents like GLP-1 receptor agonists and SGLT2 inhibitors. By integrating nutraceuticals and lifestyle-focused care, the future of PCOS management lies in personalized, long-term metabolic protection rather than a one-size-fits-all approach.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-04-01
DOI
https://doi.org/10.5281/zenodo.19327400
Primary Topic
Ovarian function and disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

EVOLVING CONCEPTS IN PCOS: DIAGNOSTIC INNOVATIONS AND NOVEL THERAPEUTIC STRATEGIES

1Sharma Upasana D., 2*Thaker Kwisha, 3Sathwara Maitri, 4Sathwara Setu, 5Barot Hinal
Zenodo (CERN European Organization for Nuclear Research)
Ovarian function and disorders
article

EVOLVING CONCEPTS IN PCOS: DIAGNOSTIC INNOVATIONS AND NOVEL THERAPEUTIC STRATEGIES

1Sharma Upasana D., 2*Thaker Kwisha, 3Sathwara Maitri, 4Sathwara Setu, 5Barot Hinal
article en

Abstract

Polycystic Ovary Syndrome (PCOS) is far more than a reproductive disorder; it is a complex endocrine and metabolic challenge affecting up to 13% of women worldwide. While traditionally viewed through the lens of fertility, modern clinical understanding now links PCOS to deep-rooted issues like insulin resistance, chronic inflammation, and emerging evidence of gut dysbiosis. This article describes the transition from "symptom management" to "precision medicine.” The article highlights how advanced diagnostic tools—such as high-sensitivity hormonal assays and AMH testing—are providing earlier, more accurate interventions. Furthermore, the shift in the therapeutic landscape has been examined, where traditional treatments are being bolstered by novel agents like GLP-1 receptor agonists and SGLT2 inhibitors. By integrating nutraceuticals and lifestyle-focused care, the future of PCOS management lies in personalized, long-term metabolic protection rather than a one-size-fits-all approach.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 7%
Ovarian function and disorders
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