Nanogel-Based Therapeutics for Psoriasis: A New Frontier in Targeted Dermatological Drug Delivery

Introduction/Objective: Psoriasis is a lifelong dermatological disorder, marked by recurring inflammatory episodes, keratinocyte hyperproliferation, epidermal thickening, and persistent immune activation. The impaired skin barrier and localized inflammation complicate effective drug delivery, while conventional therapies often exhibit poor skin bioavailability and are associated with significant systemic side effects. Methods: This review explores the role of nanogel-mediated drug delivery platforms as successful substitutes for traditional treatment approaches. It highlights the structural and functional characteristics of nanogels that contribute to improved drug delivery in psoriatic conditions. Results: Nanogels offer unique advantages through their nanoscale size, large drug-carrying ability, and sustained-release characteristics. These carriers enable: i) increased penetration through the psoriatic stratum corneum, ii) site-specific and sustained drug release at inflamed lesions, iii) increased therapeutic efficacy with reduced dosing frequency, iv) minimized systemic toxicity and adverse events, and v) potential integration of both synthetic and natural therapeutics for synergistic action. In early-stage models, nanogels have proven beneficial, showing marked improvements in Psoriasis Area and Severity Index (PASI) scores, histopathological markers, or inflammatory cytokine profiles. Discussion: Despite these promising results, concerns remain regarding immunogenicity, long-term safety, and interindividual variability in response. Furthermore, the current evidence base is largely derived from in vitro and pre-clinical studies, with limited randomized controlled clinical trials (RCTs) available. Conclusion: Future investigations must focus on carefully planned clinical studies to validate the translational potential of nanogels in psoriasis management. In light of the growing necessity for improved and well-tolerated therapies, nanogel systems represent a frontier in dermatological innovation that can transform psoriasis treatment.