DESIGN, SYNTHESIS, CHARACTERIZATION AND BACTERIALOGICAL EVALUATION OF NEWER 1,3,5 TRIAYL PYRAZOLE DERIVATIVES

This research has been successfully synthesized six compounds of 1,3,5-triaryl pyrazole derivatives by two steps reaction. Firstly, pyrazoline compound was obtained by one-pot reaction of aromatic ketones, aldehyde and hydrazine in basic condition. Then, pyrazole compound was obtained by oxidative aromatization of compound in the presense of acetic acid. Chemical structure of predicted molecules was confirmed by FTIR spectroscopy data analysis. Antibacterial activity of compounds was evaluated by Agar well diffusion Method. Biological evaluation result showed that pyrazole compounds had weak Antibacterial activity against Bacillus subtiles compare to standard drug Metronidazole.