The Conjugated Bile Acids Profile Suggests a Novel Liver‐Muscle Axis Associated With Sarcopenia in Chronic Liver Disease
Elevated C-BAs may represent a critical, liver-derived humoral factor associated with the pathological features of liver-related sarcopenia. C-BA-associated muscle mass loss and systemic inflammation are reflected at the molecular level by a shift toward a slow-twitch phenotype, accumulation of macrophages and altered energy metabolism in muscle biopsies. These findings suggest that C-BAs may serve as a potentially actionable therapeutic target for mitigating muscle catabolism and improving clinical outcomes in CLD patients.
Authors
- Makoto Nakamuta (ORCID: https://orcid.org/0000-0003-0422-8785)
- Akiko Eguchi (ORCID: https://orcid.org/0000-0002-0555-2707)
- Motoyuki Kohjima (ORCID: https://orcid.org/0000-0001-5285-3054)
- Aldo J. Montaño‐Loza (ORCID: https://orcid.org/0000-0002-2511-7980)
- Kiyora Izuoka
- Mina Tempaku
- Y. Takei
- Teruo Miyazaki (ORCID: https://orcid.org/0000-0001-9796-3011)
- Jun Okabe (ORCID: https://orcid.org/0000-0002-7196-0522)
- Yoshinao Kobayashi (ORCID: https://orcid.org/0000-0003-2447-684X)
- Hayato Nakagawa (ORCID: https://orcid.org/0000-0002-6973-5094)
- Tadashi Ikegami (ORCID: https://orcid.org/0000-0002-9216-3186)
- Yuko Takami (ORCID: https://orcid.org/0000-0002-9331-6658)
- Motoh Iwasa
- Akira Honda (ORCID: https://orcid.org/0000-0003-0902-8272)
- Naoki Yamashita (ORCID: https://orcid.org/0000-0002-6451-3206)
- Hiroshi Kitamura
Institutions
- Baker Heart and Diabetes Institute (AU)
- University of Alberta (CA)
- Mie University (JP)
- Tohoku University (JP)
- University of Alberta Hospital (CA)
- National Kyushu Medical Center (JP)
- Suzuka University (JP)
- Mie University Hospital (JP)
- Tokyo Medical University Ibaraki Medical Center (JP)
Publication Details
- Journal
- Liver International
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1111/liv.70612
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00