Transfusion‐related alpha‐gal syndrome: Two new cases expanding the demographic and geographic spectrum, and evidence of a diagnostic gap in allergic transfusion reaction evaluation
TRAGS occurs in the tick-endemic southeastern United States across a broader demographic range than previously recognized. IgA deficiency, present in <0.3% of the population, was considered in 18% of qualifying patients while alpha-gal sensitization, affecting 20%-30% in this region, was investigated in none. Integration of AGS history into pre-transfusion risk assessment and ATR evaluation protocols is warranted.
Authors
- Miriam Brown (ORCID: https://orcid.org/0000-0001-5006-7068)
- Jonathan Tucci (ORCID: https://orcid.org/0000-0001-6365-0121)
- J. Kenneth Jacobs (ORCID: https://orcid.org/0000-0002-5719-9685)
- Garrett S. Booth (ORCID: https://orcid.org/0000-0002-8422-9480)
- Kaycie Atchison (ORCID: https://orcid.org/0000-0002-8948-9396)
- Toufik Tahiri
- C. Addison Stone (ORCID: https://orcid.org/0009-0006-5720-3433)
- Deva Sharma
- Mackenzie Foster
- Angela Mueller
Institutions
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Transfusion
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1111/trf.70196
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00