IL6/IL10/TLR4 Govern Immunogenic Cell Death in Aortic Dissection
This study establishes IL6, IL10, and TLR4 as central regulators of PCD-mediated AD pathogenesis, implicating immune-vascular crosstalk and immunogenic cell death as therapeutic entry points. The identified biomarker network and drug candidates provide a translational framework for developing precision therapies against AD.
Authors
- Dongqing Chang
- Fang Wang (ORCID: https://orcid.org/0000-0001-9361-4535)
- Shaoyan Chang
- Yukui Du
- Bofeng Yu
- Li Zhang
- Liang He
Institutions
- Capital Institute of Pediatrics (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Cardiovascular Therapeutics
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1155/cdr/4140685
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00