Bridging the Scales via Personalized Cellular Modeling and Deep Phenotyping in Schizophrenia
These findings establish a patient-specific link between genetically driven alterations in gene expression, synaptic dysfunction, and large-scale brain and cognitive phenotypes in SCZ. This multiscale framework provides a foundation for mechanism-based stratification and precision target identification for cognitive impairment.
Authors
- Oliver Pogarell (ORCID: https://orcid.org/0000-0001-6455-4190)
- I. Papazova
- Tengjia Jiang (ORCID: https://orcid.org/0000-0002-7354-2199)
- Sabrina Galinski (ORCID: https://orcid.org/0000-0003-4955-527X)
- Miriam Gagliardi (ORCID: https://orcid.org/0000-0003-0156-3705)
- Michael J. Ziller (ORCID: https://orcid.org/0000-0003-0781-7980)
- Sven P. Wichert
- Tim Schäfer (ORCID: https://orcid.org/0000-0001-9468-0470)
- Peter Zill (ORCID: https://orcid.org/0000-0003-1068-5886)
- Lukas Roell
- Stephanie Behrens
- Benedikt Schworm (ORCID: https://orcid.org/0000-0003-0753-2408)
- E Schulte (ORCID: https://orcid.org/0000-0001-6432-7166)
- Karin Neumeier
- Moritz J. Rossner (ORCID: https://orcid.org/0000-0002-0667-3420)
- Katharina Hanken
- Philipp G. Sämann (ORCID: https://orcid.org/0000-0001-8523-3628)
- Lucia Trastulla (ORCID: https://orcid.org/0000-0001-8749-475X)
- Temmuz Karali
- Anna Levina (ORCID: https://orcid.org/0000-0003-1355-6617)
- Clara Vetter (ORCID: https://orcid.org/0000-0003-4268-2890)
- Florian J. Raabe (ORCID: https://orcid.org/0000-0001-8538-0783)
- Andrea Schmitt (ORCID: https://orcid.org/0000-0002-5426-4023)
- Marcus Ising (ORCID: https://orcid.org/0000-0001-5421-5777)
- Julian Melcher
- Susanne Karch (ORCID: https://orcid.org/0000-0002-1542-1110)
- D. Keeser
- Thomas Geyer (ORCID: https://orcid.org/0000-0003-2380-1188)
- Iris Jäger
- Lenka Krčmář
- Pauline Pingen
- Nadja Gabellini
- Alexandra Hisch
- Marcel S. Kallweit
- Verena Meisinger
- Fanny Dengl
- Georgios Ioannou
- CDP Working Group
- Nicole Klimas
- Sylvia de Jonge
- Matin Mortazavi
- Clara Weyer
- Susanne Schmölz
- Sophie Seeburger
- Man-Hsin Chang
- Maxim Korman
- Alessia Atella
- Alkomiet Hasan
- Christoph Kern
- Siegfried G. Priglinger
- David Popovic
- Nikolaos Koutsouleris
- Elias Wagner
- Boris Papazov
- Emanuel Boudriot
- Valeria Almeida
- Berkhan Karslı
- Laura E. Fischer
- Sergi Papiol
- Joanna Moussiopoulou
- Lina Dürrwald
- Vladislav Yakimov
- Peter Falkai
- Frank Padberg
- Enrico Schulz
- Vanessa Gabriel
- Valéria de Almeida
- Genc Hasanaj
Institutions
- University of Bonn (DE)
- University of Augsburg (DE)
- Universidade de São Paulo (BR)
- King's College London (GB)
- University of Münster (DE)
- University Hospital Bonn (DE)
- Max Planck Institute for Biological Cybernetics (DE)
- German Center for Infection Research (DE)
- Media Working Group (US)
- Bernstein Center for Computational Neuroscience Munich (DE)
- Max Planck Institute of Psychiatry (DE)
- Urologische Klinik München (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1001/jamapsychiatry.2026.0576
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00