Comparison of phase-resolved functional lung (PREFUL) MRI and CT parametric response mapping (PRM) in COSYCONET COPD

QuestionHow does regional ventilation in COPD, measured by PREFUL MRI, correspond to CT-based PRM metrics? FindingsPREFUL MRI's VDP showed strong correlation and the highest spatial agreement with the combined CT PRM metric representing emphysema and functional small airways disease. Clinical relevancePREFUL MRI offers a non-invasive, radiation-free method for assessing regional ventilation in COPD. Although PREFUL cannot distinguish emphysema from small airways disease, its strong correlation with CT PRM highlights its value for disease characterization and functional monitoring.