Unifying theories in high-dimensional biophysics: approaches, challenges and opportunities
Across biological subdisciplines, the last decade has seen an explosion of high-dimensional datasets. At the ICTS workshop ‘Unifying Theories in High-Dimensional Biophysics’, we discussed whether this high dimensionality poses a challenge or an opportunity for theoretically describing, understanding and predicting biological systems. We discussed methods, models and frameworks that can be used for this purpose. This Comment summarizes our discussions from the perspectives of individual participants.
Authors
- Suriyanarayanan Vaikuntanathan (ORCID: https://orcid.org/0000-0003-2431-6045)
- Jacopo Grilli (ORCID: https://orcid.org/0000-0002-8235-5803)
- Kabir Husain (ORCID: https://orcid.org/0000-0002-8540-3794)
- A. Dharma Raju (ORCID: https://orcid.org/0000-0002-3403-0609)
- Rahul Siddharthan (ORCID: https://orcid.org/0000-0002-2233-0954)
- Milo M. Lin (ORCID: https://orcid.org/0000-0001-8680-2685)
- Akshit Goyal (ORCID: https://orcid.org/0000-0002-9425-8269)
- Gautam Reddy (ORCID: https://orcid.org/0000-0002-1276-9613)
- Simone Pigolotti (ORCID: https://orcid.org/0000-0002-6157-6906)
- Michael M. Desai (ORCID: https://orcid.org/0000-0002-9581-1150)
- Marianne Bauer (ORCID: https://orcid.org/0000-0002-1191-986X)
- Kyogo Kawaguchi (ORCID: https://orcid.org/0000-0001-9395-9875)
- Sidhartha Goyal (ORCID: https://orcid.org/0000-0002-7452-892X)
- Aneta Koseska (ORCID: https://orcid.org/0000-0003-4263-2340)
- Krishna Shrinivas (ORCID: https://orcid.org/0000-0002-4167-9385)
- Greg J. Stephens (ORCID: https://orcid.org/0000-0003-3135-3514)
- Leelavati Narlikar (ORCID: https://orcid.org/0000-0001-6820-1878)
- Mohit Kumar Jolly (ORCID: https://orcid.org/0000-0002-6631-2109)
- Shaon Chakrabarti (ORCID: https://orcid.org/0000-0002-7429-5927)
- William Gilpin (ORCID: https://orcid.org/0000-0001-8666-6951)
- Sanjay Jain
- Andreas Tiffeau-Mayer
Institutions
- University of Delhi (IN)
- Northwestern University (US)
- Tata Institute of Fundamental Research (IN)
- The Abdus Salam International Centre for Theoretical Physics (ICTP) (IT)
- Santa Fe Institute (US)
- Pioneer (United States) (US)
- Okinawa Institute of Science and Technology Graduate University (JP)
- Okinawa University (JP)
- Indian Institute of Science Education and Research Pune (IN)
- University of Toronto (CA)
- National Centre for Biological Sciences (IN)
- Homi Bhabha National Institute (IN)
- Princeton University (US)
- Center of Advanced European Studies and Research (DE)
- University of Chicago (US)
- International Centre for Theoretical Sciences (IN)
- MRC Laboratory for Molecular Cell Biology (GB)
- Evolutionary Genomics (United States) (US)
- RIKEN Center for Advanced Intelligence Project (JP)
- Institute of Infection and Immunity (CA)
- University College London (GB)
- Indian Institute of Science Bangalore (IN)
- Institute of Mathematical Sciences (IN)
- The University of Texas at Austin (US)
- Vrije Universiteit Amsterdam (NL)
- The University of Texas Southwestern Medical Center (US)
- Delft University of Technology (NL)
Publication Details
- Journal
- npj Systems Biology and Applications
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1038/s41540-026-00680-9
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00