Pretreatment of metanephric mesenchymal cells with catalpol mitigates acute kidney injury through VEGF-A secretion via multiple mechanisms

Catalpol pretreatment enhances the therapeutic efficacy of MMCs by activating the canonical Wnt pathway to promote VEGF-A secretion. VEGF-A interacts with VEGFR2 on renal tubular epithelial cells, likely through both p38 pathway activation and STAT3 pathway inhibition, thereby suppressing inflammation, oxidative stress, and necroptosis to alleviate AKI. This study provides novel insights into the integration of traditional Chinese medicine components with stem cell therapy for AKI management.

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Publication Details

Journal
Stem Cell Research & Therapy
Published
2026-03-28
DOI
https://doi.org/10.1186/s13287-026-04914-9
Primary Topic
Chemotherapy-induced organ toxicity mitigation
Type
article
Field-Weighted Citation Impact
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article

Pretreatment of metanephric mesenchymal cells with catalpol mitigates acute kidney injury through VEGF-A secretion via multiple mechanisms

Bo Fu, Yuansheng Xie, Wenkai Guo, Quanhang Jiang et al.
Stem Cell Research & Therapy
Chemotherapy-induced organ toxicity mitigation
article

Pretreatment of metanephric mesenchymal cells with catalpol mitigates acute kidney injury through VEGF-A secretion via multiple mechanisms

Bo Fu, Yuansheng Xie, Wenkai Guo, Quanhang Jiang, Pengcheng Ji, Jingru Bi, Zhiwei Yin, Bing Han
article en

Abstract

Catalpol pretreatment enhances the therapeutic efficacy of MMCs by activating the canonical Wnt pathway to promote VEGF-A secretion. VEGF-A interacts with VEGFR2 on renal tubular epithelial cells, likely through both p38 pathway activation and STAT3 pathway inhibition, thereby suppressing inflammation, oxidative stress, and necroptosis to alleviate AKI. This study provides novel insights into the integration of traditional Chinese medicine components with stem cell therapy for AKI management.

Stem Cell Research & Therapy
Hebei Medical University (CN), Nankai University (CN), State Administration of Traditional Chinese Medicine of the People's Republic of China (CN), Tianjin First Center Hospital (CN), Chinese PLA General Hospital (CN), Second Affiliated Hospital of Jilin University (CN), Tianjin Medical University (CN)
Good health and well-being
Openalex Percentile: Top 3%
Chemotherapy-induced organ toxicity mitigation
DOIOpen Access PDFOpenAlex
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Pretreatment of metanephric mesenchymal cells with catalpol mitigates acute kidney injury through VEGF-A secretion via multiple mechanisms — Bo Fu, Yuansheng Xie, et al. · Stem Cell Research & Therapy (2026) | TGRS Research Map | TGRS