Undetectable unintegrated HIV-DNA in persons with HIV: frequency and determinants
A substantial proportion of chronically treated PWH exhibited undetectable uDNA in peripheral blood. The uDNA measurement provides complementary information to plasma HIV-1 RNA and CD4⁺ T-cell counts and may help identify individuals with no evidence of recent infection events and higher immunological fitness. These findings support the potential utility of uDNA quantification as a biomarker of HIV-1 reservoir dynamics in real-world clinical settings.
Authors
- Andrea De Maria (ORCID: https://orcid.org/0000-0001-5782-333X)
- Benedetta Canovari
- Anna Casabianca (ORCID: https://orcid.org/0000-0001-6063-7466)
- Francesco Barchiesi (ORCID: https://orcid.org/0000-0003-1098-902X)
- Chiara Giovannucci Orlandi
- Mauro Magnani
- Marco Bruno Luigi Rocchi
Institutions
- Marche Polytechnic University (IT)
- University of Urbino (IT)
- San Salvatore Hospital (IT)
- Regione Puglia (IT)
- Istituto Nazionale di Fisica Nucleare, Sezione di Genova (IT)
- University of Genoa (IT)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2026-03-28
- DOI
- https://doi.org/10.1186/s12879-026-13113-z
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00