European Journal of Biomedical AND Pharmaceutical sciences

Vaginitis is a common gynecological disease characterized by vaginal inflammation, abnormal discharge, and pruritus, which seriously affects women’s physical and mental health. Conventional treatments such as oral antibiotics, topical antifungals, and traditional Chinese medicine (TCM) lotions have limitations including high recurrence rates, adverse reactions, and poor adherence. Juyoushen (JUC), a long-acting physical antimicrobial material, has shown promising therapeutic effects in clinical practice. This systematic review aimed to comprehensively evaluate the efficacy, safety, and usability of JUC in the treatment of general vaginitis (excluding pregnancy-related cases) using data from 11 Chinese clinical manuscripts. Methods: We extracted and synthesized data from 11 high-quality Chinese clinical studies (6 randomized controlled trials [RCTs] and 5 non-RCTs) involving 987 women with general vaginitis (bacterial vaginosis [BV], vulvovaginal candidiasis [VVC], and mixed infections). Efficacy indicators included total effective rate, cure rate, and recurrence rate; safety was assessed via adverse reaction rates; usability was evaluated by adherence rate and application convenience. Results: JUC’s total effective rate (96.8%) and cure rate (84.6%) were significantly higher than conventional treatments (89.7% and 70.2%, respectively; P < 0.001). Its recurrence rate (2.1%) was drastically lower than the control group (19.8%, P < 0.001). The adverse reaction rate of JUC (0.62%) was significantly lower than conventional treatments (17.9%, P < 0.001), with only mild, transient local discomfort reported. JUC also demonstrated superior usability, with a 93%–95% adherence rate. Conclusion: JUC is a safe, effective, and user-friendly treatment for general vaginitis (BV, VVC, mixed infections), with advantages of low recurrence and minimal adverse reactions, worthy of widespread clinical promotion and application.